Abstract #4530

Topological alterations in structural brain connectivity networks are associated with survival after out-of-hospital cardiac arrest

Timo Roine^1,2, Oskari Kantonen³, Ulrika Roine¹, Sami Virtanen⁴, Jani Saunavaara^4,5, Riitta Parkkola⁴, Ruut Laitio⁶, Olli Arola⁶, Marja Hynninen⁷, Juha Martola⁸, Heli M Silvennoinen⁸, Marjaana Tiainen⁹, Risto O. Roine¹⁰, Harry Scheinin⁶, and Timo Laitio⁶

¹Department of Neuroscience and Biomedical Engineering, Aalto University School of Science, Espoo, Finland, ²Turku Brain and Mind Center, University of Turku, Turku, Finland, ³Turku PET Centre, University of Turku and the Hospital District of Southwest Finland, Turku, Finland, ⁴Department of Radiology, Turku University Hospital, University of Turku, Turku, Finland, ⁵Department of Medical Physics, Turku University Hospital, University of Turku, Turku, Finland, ⁶Division of Perioperative Services, Intensive Care and Pain Medicine, Turku University Hospital, University of Turku, Turku, Finland, ⁷Division of Intensive Care Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland, ⁸Department of Radiology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland, ⁹Department of Neurology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland, ¹⁰Division of Clinical Neurosciences, Turku University Hospital, University of Turku, Turku, Finland

Mortality after out-of-hospital cardiac arrest is high, and there is a substantial need for new biomarkers to improve the identification of patients with poor outcome. Therefore, we investigated structural brain connectivity networks in patients after out-of-hospital cardiac arrest in order to detect differences related to survival. We found decreased global efficiency and strength from MRI scans acquired in a median of 53 hours (IQR 47-64) after OHCA to be related to mortality at 6 months after OHCA. In addition, several regions with decreased strength and local efficiency were found, most significantly in the pallidum, and superior frontal and supramarginal cortices.

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