Abstract #4536

White matter fiber density and cross-section alterations in neuropathic pain after spinal cord injury

Shana Black^1,2, Andrew Janson^1,2, and Christopher R Butson^1,2,3

¹Biomedical Engineering, University of Utah, Salt Lake City, UT, United States, ²Scientific Computing and Imaging Institute, University of Utah, Salt Lake City, UT, United States, ³Neurology, Neurosurgery, and Psychiatry, University of Utah, Salt Lake City, UT, United States

Fiber-specific white matter changes were compared using fixel-based analysis between spinal cord injured subjects with chronic neuropathic pain (n=17) and spinal cord injured subjects without any pain symptoms (n=15). Fiber density, fiber cross-section (FC), and a combined measurement of fiber density and cross section (FDC) were calculated and compared between groups using multi-shell, 3-tissue constrained spherical deconvolution and connectivity-based fixel enhancement. Statistically significant increases (FWE-corrected p<0.1) in FC and FDC were identified in a posterior-inferior commissural white matter pathway, corresponding to the splenium and major forceps of the corpus callosum and regions of the retrosplenial complex.

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