Meeting Banner
Abstract #4536

White matter fiber density and cross-section alterations in neuropathic pain after spinal cord injury

Shana Black1,2, Andrew Janson1,2, and Christopher R Butson1,2,3
1Biomedical Engineering, University of Utah, Salt Lake City, UT, United States, 2Scientific Computing and Imaging Institute, University of Utah, Salt Lake City, UT, United States, 3Neurology, Neurosurgery, and Psychiatry, University of Utah, Salt Lake City, UT, United States

Fiber-specific white matter changes were compared using fixel-based analysis between spinal cord injured subjects with chronic neuropathic pain (n=17) and spinal cord injured subjects without any pain symptoms (n=15). Fiber density, fiber cross-section (FC), and a combined measurement of fiber density and cross section (FDC) were calculated and compared between groups using multi-shell, 3-tissue constrained spherical deconvolution and connectivity-based fixel enhancement. Statistically significant increases (FWE-corrected p<0.1) in FC and FDC were identified in a posterior-inferior commissural white matter pathway, corresponding to the splenium and major forceps of the corpus callosum and regions of the retrosplenial complex.

This abstract and the presentation materials are available to members only; a login is required.

Join Here