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Abstract #4541

A novel diffusion registration method with the NTU-DSI-122 template to transform free water signal fraction maps to stereotaxic space. 

Benjamin T Newman1,2, Ana Untaroiu1, and T. Jason Druzgal1,2
1Department of Radiology & Medical Imaging, Division of Neuroradiology, University of Virginia Health System, University of Virginia, Charlottesville, VA, United States, 2Brain Institute, University of Virginia, Charlottesville, VA, United States

We propose the use of the NTU-DSI-122 template as a flexible, diffusion specific, means of registering subject images to stereotaxic MNI-space for further analysis. This allows for registration to be performed based on matching white matter fiber orientation distributions, which create within tissue contrasts, unlike voxel intensity metrics. This advantage is demonstrated by observing the increased consistency of registration versus a leading intensity-based algorithm. The range of b-values present in the NTU-DSI-122 allows for tailoring to selectively register at b-values matching those acquired in an experimental cohort, providing flexibility for both single- and multi-shell acquisitions.

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