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Abstract #4543

Diffusion MRI revealed mild optic nerve fiber degeneration during Chimpanzee aging

Chun-Xia Li1, Yumei Yan1, Longchuan Li2, Todd Preuss3, James G Herndon3, Xiaoping Hu4, and Xiaodong Zhang1,3
1Yerkes Imaging Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA, United States, 2Department of Pediatric, Emory University School of Medicine, Atlanta, GA, United States, 3Division of Neuroscience and Neurological diseases, Emory University, Atlanta, GA, United States, 4Department of bioengineering, University of California, Riverside, Riverside, CA, United States

Aging effects on the optic nerve (ON) bundles of chimpanzees were investigated systematically with diffusion tensor imaging (DTI). Mean diffusivity (MD), axial diffusivity (AD or λll), radial diffusivity (RD or λτ) and fractional anisotropy (FA) showed mild and proportional changes from youth to elder adulthood, and significant increase of MD and RD were seen in elder chimpanzees. However, the changes are much milder than previous studies in the ON of monkey and human brain white matter. The unique evolution pattern in chimpanzee white mater aging may grant further investigations to unveil the neural substrate mechanism of the human brain aging.

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