Demyelination is a known pathology in AD, but it is unclear whether such myelin loss resembles primary or secondary demyelinating disease. Here, we retrospectively analysed the DTI data using voxel-wise TBSS analysis and made pair-wise comparisons between cohorts of AD, Relapsing-remitting MS(RRMS), NPSLE and normal controls (NC). In diffusion metrics analysis, widespread microstructural patterns were similarly found between AD and MS in terms of diffusion metrics, but not between AD and NPSLE. Our results indicate that the microstructural WM changes in AD may share similar pathological mechanisms in demyelinating disease of RRMS.
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