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Abstract #4551

A DTI Comparative study – Is demyelination in AD resembling primary demyelinating disease (MS) or secondary demyelinating disease (NPSLE)?

Huiqin Zhang1, Hui Zhang1, Franki Kai-Hei Tse 2, Edward Sai-Kam Hui1, Peng Cao1, Kannie Wai Yan Chan3, Queenie Chan4, Karl HERRUP5, and Henry Ka Fung Mak1
1Department of Diagnostic Radiology, The University of Hong Kong, Hong Kong, Hong Kong, 2Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong, Hong Kong, 3Department of Biomedical Engineering, City University of Hong Kong, Hong Kong, Hong Kong, 4Philips Healthcare, Hong Kong, Hong Kong, 5Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA, United States

Demyelination is a known pathology in AD, but it is unclear whether such myelin loss resembles primary or secondary demyelinating disease. Here, we retrospectively analysed the DTI data using voxel-wise TBSS analysis and made pair-wise comparisons between cohorts of AD, Relapsing-remitting MS(RRMS), NPSLE and normal controls (NC). In diffusion metrics analysis, widespread microstructural patterns were similarly found between AD and MS in terms of diffusion metrics, but not between AD and NPSLE. Our results indicate that the microstructural WM changes in AD may share similar pathological mechanisms in demyelinating disease of RRMS.

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