Abstract #4553

In vivo Diffusion Tensor Magnetic Resonance Imaging of Chronic Cocaine Administered Mouse Brain

Ethan A Cook¹, Shannon E Callen², Shilpa Buch², and Balasrinivasa R Sajja³

¹College of Medicine, University of Nebraska Medical Center, Omaha, NE, United States, ²Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, United States, ³Radiology, University of Nebraska Medical Center, Omaha, NE, United States

In vivo imaging-based biomarkers that can accurately detect the brain structural and functional changes due to chronic drug abuse play a significant role to understand and assess brain damage due to cocaine abuse and to determine the efficacy of the treatment. To this end, we have demonstrated that diffusion tensor MRI could detect brain structural changes, particularly demyelination in white matter structures, in chronic cocaine administered mice.

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