The goal of this study is to investigate a new two-step approach in intra-voxel incoherent motion (IVIM) imaging data quantification. This methods first determines the slow diffusion constant (D) then the pseudo-perfusion parameters (D*, f) using the IVIM model fitting but holding D at pre-determined value. Results show that the new approach returns more consistency parametric maps and the new modeling is favored by Akaike information criterion (AIC).