Abstract #4582

Preliminary Study on Quantitative Assessment of Fetal Brain Using MOLLI T1 Mapping Sequence

Haibo Qu^1,2, Xuesheng Li³, Fenglin Jia³, Yi Liao³, Zhijun Ye³, Pei Li³, Sai Liu³, Xinmao Ma³, Xiaoyue Zhou⁴, Qing Li⁴, and Shaoyu Wang⁵

¹West China Second University Hospital, Sichuan University, Chengdu, China, ²Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China, ³West China Second University Hospital, Chengdu, China, ⁴MR Collaborations, Siemens Healthineers Ltd., Shanghai, China, ⁵MR Scientific Marketing, Siemens Healthineers Ltd., Xian, China

A modified Look-Locker inversion recovery T1 mapping technique was used to study the development of fetal brain. Our study found the MOLLI sequence with a short scan time could reduce the impact of fetal brain movements and perform robust T1 measurements. T1 values differ in brain regions and gestational weeks (from 24 to 36). A negative correlation was found between T1 values and gestational age in thalamus, posterior limb and brain stem. Therefore, T1 measured by the MOLLI sequence could be used as a biomarker for evaluating fetal brain development.

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