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Abstract #4582

Preliminary Study on Quantitative Assessment of Fetal Brain Using MOLLI T1 Mapping Sequence

Haibo Qu1,2, Xuesheng Li3, Fenglin Jia3, Yi Liao3, Zhijun Ye3, Pei Li3, Sai Liu3, Xinmao Ma3, Xiaoyue Zhou4, Qing Li4, and Shaoyu Wang5
1West China Second University Hospital, Sichuan University, Chengdu, China, 2Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China, 3West China Second University Hospital, Chengdu, China, 4MR Collaborations, Siemens Healthineers Ltd., Shanghai, China, 5MR Scientific Marketing, Siemens Healthineers Ltd., Xian, China

A modified Look-Locker inversion recovery T1 mapping technique was used to study the development of fetal brain. Our study found the MOLLI sequence with a short scan time could reduce the impact of fetal brain movements and perform robust T1 measurements. T1 values differ in brain regions and gestational weeks (from 24 to 36). A negative correlation was found between T1 values and gestational age in thalamus, posterior limb and brain stem. Therefore, T1 measured by the MOLLI sequence could be used as a biomarker for evaluating fetal brain development.

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