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Abstract #4588

Resting State Functional Connectivity and Angiogenesis-related Gene Co-Expression Networks in early brain development

Serafeim Loukas1,2, Sandra Martin1, Joana Sa de Almeida1, Lana Vasung1,3, Dimitri Van De Ville2, Djalel Meskaldji1,4, and Petra S. Hüppi1
1Division of Development and Growth, Department of Pediatrics, University of Geneva, Geneva, Switzerland, 2Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, 3Division of Newborn Medicine, Department of Medicine, Harvard Medical School, Boston, MA, United States, 4Institute of Mathematics, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland

During early brain development, rs-functional connectivity exhibits regional and age-specific activation patterns. We hypothesize that these rs-fMRI patterns might reflect maturity of intracerebral microvascular compartment linked to spatio-temporal genetic expression patterns. The genetic patterns were explored through postmortem human brain specimens and the rs-fMRI connectivity using a longitudinal preterm dataset. rs-functional connectivity and angiogenic genes expression show spatio-temporal differences during early brain development. We observe an increased role of the primary somatosensory and motor cortices from late-fetal to neonatal periods that might be driven by an increased expression of important angiogenic genes in these regions.

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