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Abstract #4599

Depicting White Matter Developmental Trajectory Using Diffusional Kurtosis Imagingļ¼šfrom neonate through childhood

Yuli Zhang1, Xianjun Li1, Mengxuan Li1, Qinli Sun1, Miaomiao Wang1, Chao Jin1, Congcong Liu1, Fan Wu1, Xiaoyu Wang1, Huifang Zhao1, Yannan Chen1, Cong Tian1, Peiyao Chen1, Xiaocheng Wei2, and Jian Yang1
1the First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China, 22. MR Research China, GE Healthcare, Xi'an, China, China

Brain development is a complex process linked with behavioral, emotional, cognitive, especially the maturation process of WM is both of great scientific and clinical importance1. However, the lack of continuous development of WM from neonate to childhood. Diffusion kurtosis imaging(DKI)is a diffuse imaging method that reflects non-Gaussian distribution information of biological water. This study aimed to use DKI parameters depicting developmental trajectory of WM. The fractional anisotropy(FA), mean kurtosis(MK),axial kurtosis(AK),radial kurtosis(RK)positively correlated with age; the axial diffusivity(AD) radial diffusivity(RD) negativly correlated with age. These parameters changed rapidly before the age of 2 years old, and then gradually slowed down.

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