Abstract #4604

Longitudinal Assessment of Third Trimester Regional Cerebral Blood Flow in Very Preterm Infants

Zungho Zun^1,2,3,4, Kushal Kapse¹, Marni Jacobs^3,5, Sudeepta Basu^3,6, Mariam Said^3,6, Nicole Andersen¹, Jonathan Murnick^1,3,4, Taeun Chang^3,7,8, Adre du Plessis^2,3, and Catherine Limperopoulos^1,2,3,4

¹Division of Diagnostic Imaging and Radiology, Children's National Hospital, Washington, DC, United States, ²Division of Fetal and Transitional Medicine, Children’s National Hospital, Washington, DC, United States, ³Department of Pediatrics, George Washington University, Washington, DC, United States, ⁴Department of Radiology, George Washington University, Washington, DC, United States, ⁵Division of Biostatistics and Study Methodology, Children's National Hospital, Washington, DC, United States, ⁶Division of Neonatology, Children's National Hospital, Washington, DC, United States, ⁷Division of Neurology, Children's National Hospital, Washington, DC, United States, ⁸Department of Neurology, George Washington University, Washington, DC, United States

Early newborn age is a crucial phase of brain development, which can be characterized by in-vivo measurement of cerebral blood flow (CBF). In this study we assessed regional CBF in very preterm infants longitudinally during the ex-utero third trimester using arterial spin labeling. CBF in preterm infants significantly increased with postmenstrual age in all regions with the most rapid increase and the highest mean of CBF in the cerebellum. Lower CBF was associated with intraventricular hemorrhage and patent ductus arteriosus. CBF in preterm infants was higher than that of healthy full-term controls at term equivalent age.

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