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Abstract #4604

Longitudinal Assessment of Third Trimester Regional Cerebral Blood Flow in Very Preterm Infants 

Zungho Zun1,2,3,4, Kushal Kapse1, Marni Jacobs3,5, Sudeepta Basu3,6, Mariam Said3,6, Nicole Andersen1, Jonathan Murnick1,3,4, Taeun Chang3,7,8, Adre du Plessis2,3, and Catherine Limperopoulos1,2,3,4
1Division of Diagnostic Imaging and Radiology, Children's National Hospital, Washington, DC, United States, 2Division of Fetal and Transitional Medicine, Children’s National Hospital, Washington, DC, United States, 3Department of Pediatrics, George Washington University, Washington, DC, United States, 4Department of Radiology, George Washington University, Washington, DC, United States, 5Division of Biostatistics and Study Methodology, Children's National Hospital, Washington, DC, United States, 6Division of Neonatology, Children's National Hospital, Washington, DC, United States, 7Division of Neurology, Children's National Hospital, Washington, DC, United States, 8Department of Neurology, George Washington University, Washington, DC, United States

Early newborn age is a crucial phase of brain development, which can be characterized by in-vivo measurement of cerebral blood flow (CBF). In this study we assessed regional CBF in very preterm infants longitudinally during the ex-utero third trimester using arterial spin labeling. CBF in preterm infants significantly increased with postmenstrual age in all regions with the most rapid increase and the highest mean of CBF in the cerebellum. Lower CBF was associated with intraventricular hemorrhage and patent ductus arteriosus. CBF in preterm infants was higher than that of healthy full-term controls at term equivalent age.

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