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Abstract #4611

Effect of Sedation on Cerebral Metabolic Rate of Oxygen (CMRO2) in Children with Congenital Heart Disease

Pei-Hsin Wu1, Alexandra Batzdorf1, Arastoo Vossough2, Daniel J. Licht2, Mark A. Fogel2, and Felix W. Wehrli1
1Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2The Children's Hospital of Philadelphia, Philadelphia, PA, United States

CMRO2 was evaluated by MR susceptometry. The hypothesis that CMRO2 is lower in sedated young children with single ventricle heart defects (SVD) was investigated in this study. The results show that (1) lower CMRO2 was found in young subjects after administration of sevoflurane, compared to their unsedated peers, (2) brain volumes in patients with SVD were comparable to those reported in healthy children, (3) cerebral blood flow was smaller than the values reported in healthy subjects. The preliminary data indicate that results from awake and sedated subgroups cannot be pooled, at least not for the study of the neurometabolic consequences.

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