PWML with high incidence (~20%) was correlated with adverse neurodevelopment outcomes and lesions disappeared as time goes on. Although MRI can accurately evaluate PWML, currently it’s not a universal screening method. This study aimed to develop a predictive model of MRI screening for PWML based on clinical factors, and help clinicians identify which neonates should undergo MRI. 5899 neonates were recruited. Logistic regression analysis were used to develop the model. Ten independent factors were identified and the model was presented as nomogram. Current model showed good discrimination and clinically use. It will help clinicians conveniently and early make decision.