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Abstract #4648

Morphometric Similarity Better Predicts Later Cognition in Paediatric Traumatic Brain Injury than Single Structural Features

Daniel J. King1, Stefano Seri1,2, Cathy Catroppa3,4, Vicki A. Anderson3,4, and Amanda G. Wood1,5
1School of Life and Health Sciences & Aston Neuroscience Institute, Aston University, Birmingham, United Kingdom, 2Department of Clinical Neurophysiology, Birmingham Women’s and Children’s Hospital NHS Foundation Trust, Birmingham, United Kingdom, 3Brain and Mind Research, Clinical Sciences, Murdoch Children’s Research Institute, Melbourne, Australia, 4Department of Psychology, Royal Children’s Hospital, Melbourne, Australia, 5School of Psychology, Faculty of Health, Melbourne Burwood Campus, Deakin University, Geelong, Victoria, Australia

Neuroanatomical correlates of long-term cognitive impairment after a paediatric traumatic brain injury are not established. Acutely acquired T1w MPRAGE MRI scans were used to calculate morphometric similarity between cortical areas. A supervised learning approach showed that, after cross-validation, morphometric similarity explained 12% variance in cognitive functioning two-years post-injury, beyond that of individual structural features. Thus, morphometric similarity is a useful approach to understand the diffuse effects of neurological insult on the still-developing brain and how this may predict later neuropsychological functioning.

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