Abstract #4670

How does Microstructural in lntra-axonal and Extra-axonl Space Change in Preterm Infants with Punctate White Matter Lesions?

Mengxuan Li¹, Xianjun Li¹, Yuli zhang¹, Miaomiao Wang¹, Yannan Cheng¹, Congcong Liu¹, Chao Jin¹, Fan Wu¹, Xiaoyu Wang¹, Huifang Zhao¹, Cong Tian¹, Peiyao Chen¹, Xiaocheng Wei², and Jian Yang¹

¹Radiology, the First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China, Xi'an, China, ²MR Research China, GE Healthcare, Bei Jing, China

Punctate white matter lesions (PWML)are common in preterm infants.Extensive microstructural changes were observed previously for different PWML grades by using diffusion tensor imaging (DTI).However, the changes of intra-axon and extra-axon remain to be investigated. White matter tract integrity (WMTI)metrics derived from diffusion kurtosis imaging (DKI)provide information of intra-axonal or extra-axonal spaces. Our study aimed to use WMTI metrics to detect the Microstructural Variations.Compared to DTI metrics, the change trends of fractional anisotropy (FA),axial diffusivity (AD) and radial diffusivity (RD)are in agreement with previous findings.Furthermore, intra-axonal diffusivity (Da)unchange or reduce in lntra-axonal space.There were increased RDe, reduced/unchanged ADe in extra-axonal space.

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