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Abstract #4681

Characterization of brain metabolite changes in early childhood

Ashley D Harris1,2, Tiffany Bell1,2, Mercedes Bagshawe1,2, Elodie Boudes1,2, and Catherine Lebel1,2
1Radiology, University of Calgary, Calgary, AB, Canada, 2Alberta Children's Hospital Research Institute and the Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada

Using proton MRS, we examine longitudinal changes in tNAA, tCr, tCho, Ins and Glx in early childhood in a typically developing children ages 2.4-9.3 years. We show NAA increases in the anterior cingulate across both sexes while age-relate changes in NAA in the left angular gyrus are only seen in boys. In the anterior cingulate tCr in girls increases and tCho decreases in boys. By contrast in the left angular gyrus tCr increases in boys and tCho decreases in girls. These different metabolite trajectories in different brain regions may be associated with different development seen between boys and girls.

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