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Abstract #4685

Uptake of MRI and associated data quality in an inclusive clinical trial in children with Autism Spectrum Disorder

Marilena M DeMayo1, Izabella M Pokorski1, Ian B Hickie2, and Adam J Guastella1
1University of Sydney, Camperdown, Australia, 2Brain and Mind Centre, University of Sydney, Camperdown, Australia

Individuals with Autism Spectrum Disorder (ASD) show high rates of comorbidities, including intellectual disability. Often, individuals with comorbid conditions are excluded from clinical trials and neuroimaging studies, potentially biasing the development of treatments and subtypes. In an inclusive trial (without functioning constraints) for children with ASD (aged 3-12 years), 71 participants consented to MRI and 24 (34%) completed an MRI scan, following a familiarization procedure. Twenty-one participants had a successful post-treatment MRI. This study reports on the resultant data quality and shows the potential to include MRI in trials of complex populations who, typically, are excluded.

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