We show dynamic variations in brain ventricle volume (VV) in longitudinal MRI scans of pediatric patients with acute disseminated encephalomyelitis (ADEM). A majority of patients showed decreases in VV directly following the initial clinical event, or following subsequent VV expansion. This suggests that the VV expansion in these patients was not due to irreversible brain atrophy, but rather likely reflected processes associated with acute disease. Calculations of VV (and volumes of other brain structures) done using the automated tool FreeSurfer were significantly affected by gadolinium-based contrast agents; comparing pre- and post-contrast scans should be avoided in longitudinal studies.
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