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Abstract #4722

Quantitative imaging of adipocyte distribution in breast cancer xenograft models

Michal Tomaszewski1, William Dominguez Viqueira1, Bruna Victorasso Jardim Perassi1, Pravin Phadatare1, Robert J Gillies1, and Smitha Pillai1
1Cancer Physiology, H. Lee Moffitt Cancer Center, Tampa, FL, United States

Lipid deposition and metabolism is relevant for cancer prognosis and treatment response. Imaging characterisation of the adipocyte deposition patterns in breast cancer and its relationship with the microenvironment may therefore provide valuable insight into the tumour. A Chemical selected saturation based MR technique was optimised and validated in vivo and ex vivo to visualize adipocyte distribution in breast cancer xenografts. The measurements reveal clear differences in adipocyte accumulation between different breast models. In the future this technique will be applied to understand the role of adipocyte distribution in breast cancer.

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