A iAUC derived tumor permeability index factor (TPIF) provides a reliable and robust reporter of breast cancer brain metastases (BCBM) tumor microenvironment permeability patterns without the confounding elements of model-based DCE-MRI analysis (i.e. low sensitivity, inability to fit, inter-subject data reliability). A comparison of results in both mice and patients suggests that this parameter can serve as an additional tool for improved, early clinical diagnosis and for therapeutic testing at the preclinical level.
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