Abstract #4730

IAUC derived permeability index factor is a robust parameter for permeability visualization in breast cancer brain metastasis in mice & patients.

Daniele Procissi¹, Supada Prakkamakul^2,3, Sol Misener⁴, Nicola Bertolino⁴, Benjamin P Liu ², and Irina Balyasnikova⁵

¹Radiology & Biomedical Engineering, Northwestern University, Evanston, IL, United States, ²Radiology, Northwestern Memorial Hospital, Chicago, IL, United States, ³Diagnostic Radiology, Samitivej Hospital, Bangkok, Thailand, ⁴Radiology, Northwesten Unversity, Chicago, IL, United States, ⁵Neurological Surgery, Northwestern, Chicago, IL, United States

A iAUC derived tumor permeability index factor (TPIF) provides a reliable and robust reporter of breast cancer brain metastases (BCBM) tumor microenvironment permeability patterns without the confounding elements of model-based DCE-MRI analysis (i.e. low sensitivity, inability to fit, inter-subject data reliability). A comparison of results in both mice and patients suggests that this parameter can serve as an additional tool for improved, early clinical diagnosis and for therapeutic testing at the preclinical level.

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