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Abstract #4730

IAUC derived permeability index factor is a robust  parameter for permeability visualization in breast cancer brain metastasis in mice & patients.

Daniele Procissi1, Supada Prakkamakul2,3, Sol Misener4, Nicola Bertolino4, Benjamin P Liu 2, and Irina Balyasnikova5
1Radiology & Biomedical Engineering, Northwestern University, Evanston, IL, United States, 2Radiology, Northwestern Memorial Hospital, Chicago, IL, United States, 3Diagnostic Radiology, Samitivej Hospital, Bangkok, Thailand, 4Radiology, Northwesten Unversity, Chicago, IL, United States, 5Neurological Surgery, Northwestern, Chicago, IL, United States

A iAUC derived tumor permeability index factor (TPIF) provides a reliable and robust reporter of breast cancer brain metastases (BCBM) tumor microenvironment permeability patterns without the confounding elements of model-based DCE-MRI analysis (i.e. low sensitivity, inability to fit, inter-subject data reliability). A comparison of results in both mice and patients suggests that this parameter can serve as an additional tool for improved, early clinical diagnosis and for therapeutic testing at the preclinical level.

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