Abstract #4734

Response Evaluation in Osteosarcoma: RECIST1.1 criteria Versus Intravoxel Incoherent Motion

Esha Baidya Kayal¹, Devasenathipathy Kandasamy², Kedar Khare³, Sameer Bakhshi⁴, Raju Sharma², and Amit Mehndiratta^1,5

¹Centre for Biomedical Engineering, Indian Institute of Technology, Delhi, New Delhi, India, ²Radio Diagnosis, All India Institute of Medical Sciences, New Delhi, New Delhi, India, ³Department of Physics, Indian Institute of Technology, Delhi, New Delhi, India, ⁴Department of Medical Oncology, Dr. B.R. Ambedkar Institute-Rotary Cancer Hospital (IRCH), All India Institute of Medical Sciences, New Delhi, New Delhi, India, ⁵Department of Biomedical engineering, All India Institute of Medical Sciences, New Delhi, New Delhi, India

Osteosarcoma (OS) is the most common primary malignant bone tumor in children and adolescents. Monitoring treatment response during chemotherapy might help in better and personalized therapeutic options improving overall therapeutic outcome. RECIST1.1 is the standard imaging based non-invasive treatment response evaluation criteria in solid tumors. Quantitative Intravoxel incoherent motion (IVIM) parameters and their histogram analysis were performed in Osteosarcoma in characterizing chemotherapy response with respect to RECIST1.1 criteria. IVIM parameters and its histogram analysis revealed clinically useful information in characterizing chemotherapy response in Osteosarcoma.

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