Meeting Banner
Abstract #4747

3D T2 mapping with dictionary-based matching in simultaneous PET/MR: a preliminary study in prostate cancer patients

Elisa Roccia1, Radhouene Neji1,2, Meghana Kulkarni3, Thomas Benkert4, James Stirling3, Sami Jeljeli3, Berthold Kiefer4, Gary Cook3, Vicky Goh3, and Isabel Dregely1
1Biomedical Engineering Department, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, 2Siemens Healthcare Limited, Frimley, United Kingdom, 3Cancer Imaging Department, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, 4Siemens Healthcare GmbH, Erlangen, Germany

In this work we aim to show the clinical feasibility of quantitative 3D T2 mapping for tissue characterization and with the potential for prostate cancer detection. We implemented a 3D T2-prepared multi-shot gradient echo sequence and a dictionary matching approach for quantitative T2 analysis. We tested it in three biopsy-proven prostate cancer patients who underwent a simultaneous 18F-Choline PET/MR scan. Quantitative T2 matched literature values and we observed reduced T2 in lesions compared to normal peripheral zone tissue even in only moderately differentiated cancers (Gleason 3+4). Lesion location matched uptake of simultaneously acquired 18F-Choline PET.

This abstract and the presentation materials are available to 2020 meeting attendees and eLibrary customers only; a login is required.

Join Here