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Abstract #4752

Imaging and pain response in extra vs intra-pelvic recurrent gynaecological tumours treated with MR guided HIFU: a pilot study

Georgios Imseeh1,2, Sharon L Giles3, Ian Rivens4, Alexandra Taylor2, Gail ter Haar4, Erica Scurr3, and Nandita M deSouza1,3
1Imaging, Institute of Cancer Research, Sutton, Surrey, United Kingdom, 2Clinical Oncology, The Royal Marsden NHS Foundation Trust, London, United Kingdom, 3MRI Unit, The Royal Marsden NHS Foundation Trust, Surrey, United Kingdom, 4Therapy Ultrasound, Institute of Cancer Research, Sutton, Surrey, United Kingdom

MR guided High Intensity Focused Ultrasound in 10 patients with symptomatic recurrent gynecological tumors treated for pain palliation resulted in higher temperatures in shallower extra-pelvic tumors compared to intra-pelvic ones (62.9±11.7oC vs. 49.4±2.8oC over median 16 sec sonication) despite lower energy delivery in them (39.1±23.6 kJ vs. 72.1±24.3 kJ). In 3 of 5 extra-pelvic tumors, an increase in the non-perfused tumor volume immediately after treatment was seen, indicating edema. At Day 30, 5 patients met the criteria of pain response, 3 with extra-pelvic tumors and 2 with intra-pelvic tumors.

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