Abstract #4770

Controlling Apparent Diffusion and Kurtosis with Vesicle Size in Quantitative Diffusion Kurtosis Phantoms

Scott D. Swanson¹, Dariya I. Malyarenko¹, Alan M. McLean², Mario L. Fabiilli¹, and Thomas L. Chenevert¹

¹Department of Radiology, University of Michigan, Ann Arbor, MI, United States, ²Department of Chemistry, University of Michigan, Ann Arbor, MI, United States

Chemical composition of lamellar lipid vesicles determines particle diameter and hence the size of a restricted diffusion component. Phantoms made at 1% by weight solid using cetearyl alcohol and cetyl trimethyl ammonium bromide with varying molar ratios have different apparent diffusion constants and kurtosis values. Vesicle sizes are confirmed by dynamic light scattering and electron microscopy. These molecular vesicles provide a basis for a quantitative diffusion phantom and future MR studies of nanoscopic domains.

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