Abstract #4773

Novel glioblastoma infiltration biomarker validation by histopathologic assessment of the relation between ADC and tumor cellularity

Antoine Vallatos¹, Haitham Al-Mubarak², Joanna Birch³, Adam Waldman¹, William Holmes², Anthony Chalmers³, and Gerard Thompson¹

¹Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom, ²Glasgow Experimental MRI Centre, Institute of Neuroscience and Psychology, University of Glasgow, Glasgow, United Kingdom, ³Wolfson Wohl Translational Cancer Research Center, Institute of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom

This work quantitatively and qualitatively assesses the relation between tumor related cellularity variation and ADC values. We show that the ADC slope along linear profiles perpendicular to the boundary voxels of the ADC region of interest is a a biomarker of tumor infiltration beyond the contrast enhancing regions. We demonstrate the existence of a strong relation between ADC and tumor cellularity and show that a vectorial profile analysis of ADC maps could provide with a robust biomarker of glioblastoma cell infiltration.

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