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Abstract #4775

Preliminary feasibility study of MR Q-space trajectory imaging (QTI) for assessment of tissue microstructure in prostate cancer

Bjoern Jan Langbein1,2,3, Filip Szczepankiewicz1,2,4, Carl-Fredrik Westin 1,2, Adam Kibel2,5, Clare Tempany1,2, Martin Schostak3, Andriy Fedorov1,2, and Fiona Fennessy 1,2
1Brigham and Women’s Hospital, Department of Radiology, Boston, MA, United States, 2Harvard Medical School, Boston, MA, United States, 3Universitätsklink Magdeburg, Magdeburg, Germany, 4Clinical Sciences Lund, Lund University, Lund, Sweden, 5Brigham and Women’s Hospital, Division of Urology, Boston, MA, United States

Q-space trajectory imaging (QTI) has shown promise for characterisation of tissue microstructure. This study seeks to determine if QTI is feasible in assessment of prostate cancer (PCa) and to prefrom a preliminary evaluation of its role to help identify clinically significant prostate cancer (Gleason Grade group ≥2 lesions). QTI was performed in 40 men, 16 of which had biopsy-proven PCa and a PIRADS v.2.1 score ≥3. Preliminary data suggest that quantification of QTI values may indeed be helpful in men with clinically significant disease.

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