Abstract #4775

Preliminary feasibility study of MR Q-space trajectory imaging (QTI) for assessment of tissue microstructure in prostate cancer

Bjoern Jan Langbein^1,2,3, Filip Szczepankiewicz^1,2,4, Carl-Fredrik Westin ^1,2, Adam Kibel^2,5, Clare Tempany^1,2, Martin Schostak³, Andriy Fedorov^1,2, and Fiona Fennessy ^1,2

¹Brigham and Women’s Hospital, Department of Radiology, Boston, MA, United States, ²Harvard Medical School, Boston, MA, United States, ³Universitätsklink Magdeburg, Magdeburg, Germany, ⁴Clinical Sciences Lund, Lund University, Lund, Sweden, ⁵Brigham and Women’s Hospital, Division of Urology, Boston, MA, United States

Q-space trajectory imaging (QTI) has shown promise for characterisation of tissue microstructure. This study seeks to determine if QTI is feasible in assessment of prostate cancer (PCa) and to prefrom a preliminary evaluation of its role to help identify clinically significant prostate cancer (Gleason Grade group ≥2 lesions). QTI was performed in 40 men, 16 of which had biopsy-proven PCa and a PIRADS v.2.1 score ≥3. Preliminary data suggest that quantification of QTI values may indeed be helpful in men with clinically significant disease.

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