Myeloma-specific renal changes are of particular interest for the prognosis and therapy monitoring of patients suffering from multiple myeloma. Here we present initial results for the evaluation of myeloma-specific renal changes by diffusion-weighted MR-imaging. Renal cortical and medullar ADC and FA values of myeloma kidney exhibit a good correlation with renal function. Cortical ADC and cortical and medullar FA values show trends to reflect myeloma-specific renal changes measured by proteinuria, serum kappa/lambda-ratio and ß2-microglobulin concentration. Diffusion-weighted MR-imaging could therefore be an important tool for monitoring myeloma-specific renal changes.