Abstract #4783

Evaluation of diffusion-weighted MR imaging for the characterization of myeloma-specific renal changes: initial results.

Alexandra Ljimani¹, Lukas Prehm¹, Julia Stabinska¹, Eric Bechler¹, Romans Zukovs², Anja Müller-Lutz¹, Miriam Frenken¹, Elisabeth Appel¹, and Hans-Jörg Wittsack¹

¹Department of Diagnostic and Interventional Radiology, University Duesseldorf, Duesseldorf, Germany, ²Department of Haematology, Oncology and Clinical Immunology, University Duesseldorf, Duesseldorf, Germany

Myeloma-specific renal changes are of particular interest for the prognosis and therapy monitoring of patients suffering from multiple myeloma. Here we present initial results for the evaluation of myeloma-specific renal changes by diffusion-weighted MR-imaging. Renal cortical and medullar ADC and FA values of myeloma kidney exhibit a good correlation with renal function. Cortical ADC and cortical and medullar FA values show trends to reflect myeloma-specific renal changes measured by proteinuria, serum kappa/lambda-ratio and ß2-microglobulin concentration. Diffusion-weighted MR-imaging could therefore be an important tool for monitoring myeloma-specific renal changes.

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