Abstract #4794

Multiparametric MRI to assess physiological changes induced by an anticancer therapy in neuroblastoma

Georgia Kanli¹, Delphine Sauvage², Elodie Viry², Manon Bosseler ², Bassam Janji², and Olivier Keunen¹

¹Translational Radiomics Group, Quantitative Biology Unit, Luxembourg Institute of Health, Luxembourg, Luxembourg, ²Laboratory of Experimental Cancer Research, Department of Oncology, Luxembourg Institute of Health, Luxembourg, Luxembourg

Neuroblastoma (NB) is the most common extracranial solid tumor in childhood. High-risk patients have still a poor prognosis despite the therapeutic progress. The aim of this study is to assess by Magnetic Resonance Imaging (MRI) the physiological changes (perfusion and hypoxia) induced by an experimental anticancer therapy tested in a well-characterized preclinical transgenic neuroblastoma murine model. Our results show a decrease of the Ktrans parameter and relaxivity R2* value in treated mice compared to control, suggesting an impact of such therapy on vessels normalization.

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