Abstract #4805

Lipid composition in breast tumours using double quantum filtered correlation spectroscopy is associated with lymphovascular invasion (LVI)

Sai Man Cheung¹, Ehab Husain², Yazan Masannat³, Vasiliki Mallikourti¹, Steven Heys³, and Jiabao He¹

¹Aberdeen Biomedical Imaging Centre, University of Aberdeen, Aberdeen, United Kingdom, ²Pathology Department, Aberdeen Royal Infirmary, Aberdeen, United Kingdom, ³Breast Unit, Aberdeen Royal Infirmary, Aberdeen, United Kingdom

Lymphovascular invasion (LVI) is associated with increased recurrence and metastatic risk in breast cancer. LVI amplifies the impact of genetic mutations on lipid regulation, leading to the deregulation of lipid composition. Currently LVI is estimated using the biopsy sample, while definitive LVI can only be determined after surgery, precluding patients on neoadjuvant chemotherapy or hormonal treatment. Double quantum filtered correlation spectroscopy (DQF-COSY) is a method capable of accurate non-invasive lipid composition quantification. We therefore examined the role of lipid composition using DQF-COSY in differentiating the status of LVI.

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