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Abstract #4811

Elevation in lactate concentration and intracellular pH is less pronounced in IDH mutant compared to IDH wildtype glioma patients

Katharina Wenger1, Joachim P. Steinbach2, Oliver Bähr2, Ulrich Pilatus1, and Elke Hattingen1
1Neuroradiology, Goethe-University Frankfurt, Frankfurt, Germany, 2Neurooncology, Goethe-University Frankfurt, Frankfurt, Germany

Preclinical evidence points towards a metabolic reprogramming in isocitrate dehydrogenase mutated tumor cells with downregulation of the expression of genes that encode for glycolytic metabolism. We non-invasively investigated lactate concentrations, as well as intracellular pH using 1H and 31P MRS in a glioma patient cohort. At TE 97 ms, lactate peaks can be fitted with little impact of lipid/macromolecule contamination. We found a significant difference in lactate concentrations and intracellular pH comparing tumor voxels of IDH mutatet to IDH wildtype patients, with reduced lactate levels and near normal intracellular pH in IDHmut patients.

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