Abstract #4813

Antitumor effects of NK-derived nanovesicles in a B-cell lymphoma preclinical model by integrating in vivo MRI and ex vivo MRS

Rossella Canese¹, Maria Elena Pisanu¹, Mattea Chirico¹, Daniele Macchia², Massimo Spada², Egidio Iorio¹, Serena Cecchetti³, Cristina Federici⁴, and Luana Lugini⁴

¹NMR and MRI unit, Core facilities, Istituto Superiore di Sanita', Rome, Italy, ²National Center for animal experimentation and welfare, Istituto Superiore di Sanita', Rome, Italy, ³Microscopy unit, Core facilities, Istituto Superiore di Sanita', Rome, Italy, ⁴Oncology and Molecular Medicine Department, Istituto Superiore di Sanita', Rome, Italy

NK cells (NK) are the first barrier of body defense from tumor cells. Individuals with low NK activity display an increased risk to develop cancer. Extracellular vesicles are secreted vesicles possessing immune regulatory properties. We demonstrated that exosomes produced by NK cells (isolated from blood of healthy donors) display a cytotoxic activity against tumors in vitro. In this work we monitor the effects of NKEVs treatment by in vivo MRI/MRS and ex vivo MRS metabolomics in a xenograft model of lymphoma. We found altered lipid and redox metabolism suggesting taurine and lipid signals as potential biomarkers of NKEVs response

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