Meeting Banner
Abstract #4813

Antitumor effects of NK-derived nanovesicles in a B-cell lymphoma preclinical model by integrating in vivo MRI and ex vivo MRS

Rossella Canese1, Maria Elena Pisanu1, Mattea Chirico1, Daniele Macchia2, Massimo Spada2, Egidio Iorio1, Serena Cecchetti3, Cristina Federici4, and Luana Lugini4
1NMR and MRI unit, Core facilities, Istituto Superiore di Sanita', Rome, Italy, 2National Center for animal experimentation and welfare, Istituto Superiore di Sanita', Rome, Italy, 3Microscopy unit, Core facilities, Istituto Superiore di Sanita', Rome, Italy, 4Oncology and Molecular Medicine Department, Istituto Superiore di Sanita', Rome, Italy

NK cells (NK) are the first barrier of body defense from tumor cells. Individuals with low NK activity display an increased risk to develop cancer. Extracellular vesicles are secreted vesicles possessing immune regulatory properties. We demonstrated that exosomes produced by NK cells (isolated from blood of healthy donors) display a cytotoxic activity against tumors in vitro. In this work we monitor the effects of NKEVs treatment by in vivo MRI/MRS and ex vivo MRS metabolomics in a xenograft model of lymphoma. We found altered lipid and redox metabolism suggesting taurine and lipid signals as potential biomarkers of NKEVs response

This abstract and the presentation materials are available to 2020 meeting attendees and eLibrary customers only; a login is required.

Join Here