Recently texture analysis(TA) of MR images has also shown promising results in evaluating response to therapy in different types of cancer. TA uses mathematical approach to characterize the spatial distribution of signal intensity variations in an image and extracts quantitative features thus may infer clinically relevant information about tissue microstructure and its subtle changes during treatment. We examined efficacy of MRI based statistical TA methods in evaluating chemotherapy response in Osteosarcoma early in the course of treatment with correlation to histological response. Experimental results showed statistical TA methods may be effectively used in evaluating chemotherapy response in patient with Osteosarcoma.
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