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Abstract #4824

Texture Analysis in Chemotherapy Response Evaluation in Osteosarcoma: A Preliminary Study

Esha Baidya Kayal1, Devasenathipathy Kandasamy2, Raju Sharma2, Sameer Bakhshi3, and Amit Mehndiratta1,4
1Centre for Biomedical Engineering, Indian Institute of Technology, Delhi, New Delhi, India, 2Radio Diagnosis, All India Institute of Medical Sciences, New Delhi, New Delhi, India, 3Department of Medical Oncology, Dr. B.R. Ambedkar Institute-Rotary Cancer Hospital (IRCH), All India Institute of Medical Sciences, New Delhi, New Delhi, India, 4Department of Biomedical engineering, All India Institute of Medical Sciences, New Delhi, New Delhi, India

Recently texture analysis(TA) of MR images has also shown promising results in evaluating response to therapy in different types of cancer. TA uses mathematical approach to characterize the spatial distribution of signal intensity variations in an image and extracts quantitative features thus may infer clinically relevant information about tissue microstructure and its subtle changes during treatment. We examined efficacy of MRI based statistical TA methods in evaluating chemotherapy response in Osteosarcoma early in the course of treatment with correlation to histological response. Experimental results showed statistical TA methods may be effectively used in evaluating chemotherapy response in patient with Osteosarcoma.

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