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Abstract #4849

Multiparametric MRI with cluster analysis for early assessment of radiotherapy response in a human small-intestine neuroendocrine tumor model

Mikael Montelius1, Lukas Lundholm1, Oscar Jalnefjord1, Emman Shubbar1, Eva Forssell-Aronsson1, and Maria Ljungberg1
1Radiation Physics, Clinical Sciences, Gothenburg, Sweden

The diffusion coefficient (D) and T2* reflect clinically significant tumor characteristics, including cellularity and hypoxia. Methods to non-invasively assess D and T2* at diagnosis and early follow up are desired. The aim of this work was to evaluate the sensitivity of D and T2* to radiotherapy effects in a neuroendocrine tumor model, and to evaluate clustering as an objective method to facilitate D and T2* analysis. 20 mice were examined using MRI before and repeatedly for 2 weeks after tumor irradiation (8Gy) . We show that D and T2* are potential response biomarkers, and that clustering improves response prediction for T2*.

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