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Abstract #4855

Heterogeneity of cellularity in breast cancer from diffusion q-space MRI

Nicholas Senn1, Ehab Husain2, Yazan Masannat3, Sai Man Cheung1, Bernard Siow4, Steven D Heys5, and Jiabao He1
1Aberdeen Biomedical Imaging Centre, University of Aberdeen, Aberdeen, United Kingdom, 2Pathology department, Aberdeen Royal Infirmary, Aberdeen, United Kingdom, 3Breast Unit, Aberdeen Royal Infirmary, Aberdeen, United Kingdom, 4Francis Crick Institute, London, United Kingdom, 5School of Medicine, University of Aberdeen, Aberdeen, United Kingdom

Breast cancers often present a spatially heterogenous response to treatment manifesting as diverse variations in the underlying distribution of cellularity. We hypothesised that kurtosis from diffusion q-space imaging provides a higher effect gradient to assess the amount of entropy and dispersion in breast cancer cellularity than measures of diffusion displacement. We investigated whole breast tumours excised from surgery, with imaging performed same day overnight on a clinical 3T MRI system. The entropy and dispersion obtained from kurtosis were significantly higher than that obtained from displacement measurements, yielding a higher effect gradient, and significantly correlated with the histologic cellularity.

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