Dynamic contrast-enhanced MRI kinetic parameters have been investigated to assess the response to neoadjuvant chemotherapy (NAC). However, those studies have predictive value only after one or two cycles of NAC treatment and involves injection of contrast agent. Moreover, breast tumor sample is graded clinically using biopsy and is invasive. Aim of this study is to evaluate any correlation between MRE stiffness and clinical grading in breast carcinoma and if MRE can predict the response to NAC. Preliminary results show moderate correlation between MRE-derived stiffness and clinical grading in breast carcinoma patients.