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Abstract #4874

Molecular Effects of Chemotherapeutic Agents on Choline Phospholipid Metabolism of Triple Negative Breast Cancer Cells

Caitlin M Tressler1, Kanchan Sonkar1, Vinay Ayyappan1, Menglin Cheng1, and Kristine Glunde1
1Johns Hopkins University, Baltimore, MD, United States

Magnetic resonance spectroscopy (MRS) of breast cancer patients has shown a significant decrease in total choline (tCho) signal in patients responding to chemotherapy.1-4 Despite the clinical development of tCho as an imaging biomarker for response to chemotherapy, little is known about the molecular mechanism driving this observed change. We examined six chemotherapy agents in two triple negative breast cancer (TNBC) cell lines by high resolution (HR) 1H MRS to determine the impact of chemotherapy treatment on choline metabolites. Furthermore, we have begun to probe the impact of these chemotherapy agents on important genes in choline metabolism using quantitative real-time PCR.

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