Abstract #0011

High-resolution T1 Mapping of High-grade Glioma

Zhibo Zhu¹, Jay Acharya², Yannick Bliesener¹, R. Marc Lebel^3,4, Richard Frayne^3,5, and Krishna S. Nayak^1,2

¹Ming Hsieh Department of Electrical and Computer Engineering, University of Southern California, Los Angeles, CA, United States, ²Department of Radiology, University of Southern California, Los Angeles, CA, United States, ³Radiology and Clinical Neuroscience, Hotchkiss Brain Institute, University of Calgary, Calgray, AB, Canada, ⁴Global MR Applications & Workflow, GE Healthcare, Calgary, AB, Canada, ⁵Seaman Family MR Research Centre, Foothills Medical Centre, Calgary, AB, Canada

Native T₁ mapping is necessary for quantitative DCE-MRI of brain tumor and may have independent predictive value. Previous investigations using coarse spatial resolution have found tumor to have longer T₁ compared to normal white matter. In this work, we evaluate a recent millimeter-resolution whole-brain T₁ mapping approach in patients with high-grade glioma. T₁ values in tumor and peritumoral regions were higher than that of normal white matter, consistent with literature. We also observed T₁ spatial heterogeneity in these regions, further supporting the need for high resolution pre-contrast T₁ mapping for quantitative DCE-MRI.

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