Abstract #0027

About the origin of viscosity in MR-Elastography: tissue absorption or vascular scattering?

Giacomo Annio^1,2, Omar Darwish², Elijah Van Houten³, Knut Solna⁴, Sverre Holm⁵, and Ralph Sinkus^1,2

¹LVTS, INSERM U1148, Paris, France, ²Department of Biomedical Engineering, King's College London, London, United Kingdom, ³Département de Génie Mécanique, Université de Sherbrooke, Sherbrooke, QC, Canada, ⁴Department of Mathematics, University of California at Irvine, Irvine, CA, United States, ⁵Department of Physics, University of Oslo, Oslo, Norway

MRE is a novel tool to study in-vivo biomechanics. Recently, the diagnostic value of viscosity has been explored. However, its physical origin as intrinsic absorption or due to scattering is yet unknown. This work shows that the majority of viscosity at about 100Hz is apparent, thus originating mainly from scattering. Moreover, we observed that the classical springpot model fails to describe the dispersion properties of complex media containing scattering structures. We propose a nonlocal viscoelastic model that can ultimately disentangle intrinsic loss effects from scattering-induced ones. This changes dramatically the way we interpret viscous changes for therapies impacting on vasculature.

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