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Abstract #0053

Diffusion weighted and kurtosis breast cancer imaging for b=0-1800 s/mm2: Comparisons to dynamic contrast enhanced MRI

Martins Otikovs1, Noam Nissan2, Edna Furman-Haran1, Debbie Anaby2, Tanir M. Allweis3, Ravit Agassi4, Miri Sklair-Levy2,5, and Lucio Frydman1
1Weizmann Institute of Science, Rehovot, Israel, 2Sheba Medical Center, Ramat Gan, Israel, 3Kaplan Medical Center, Rehovot, Israel, 4Ben Gurion University Hospital, Beer Sheba, Israel, 5Tel Aviv University, Tel Aviv, Israel

Spatiotemporal encoding (SPEN) is an alternative ultrafast imaging technique which allows to overcome distortions otherwise observed along EPI’s phase-encoded dimension, and to perform self-referenced phase corrections in interleaved diffusion weighted imaging (DWI) scans. This study compares SPEN’s performance against multishot read-out segmented EPI (RESOLVE), with an emphasis on high-b-valued DWI and diffusion kurtosis imaging in the context of breast cancer imaging. The results show SPEN’s advantages for delivering kurtosis maps that provide a separation between cancerous and healthy tissues. The potential of using SPEN DW images acquired with high b-values as an alternative to DCE subtractions is also assessed.

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