Breast cancers are complex, evolving systems characterized by profound spatial and temporal heterogeneity in their biological nature. A multimodal multiparametric approach is needed to synergistically use imaging methods with different biophysical basis to simultaneously quantify multiple aspects of tumor physiology. We built a custom breast coil to allow multimodal near-infrared diffuse optical tomography and MR elastography imaging of human breast. Results of a three-inclusion dual-contrast phantom showed clear contrasts in reconstructed mechanical and optical properties as expected. Data on a breast cancer patient showed collocated hemoglobin and stiffness contrast at the tumor location.
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