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Abstract #0061

Multimodal magnetic resonance elastography and optical imaging of breast cancer

Bin Deng1,2,3, Mansi Saksena2,3, Steven Jay Isakoff3,4, Ralph Sinkus5, Samuel Patz3,6, and Stefan Alexandru Carp1,2,3
1Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, 2Department of Radiology, Massachusetts General Hospital, Boston, MA, United States, 3Harvard Medical School, Boston, MA, United States, 4Cancer Center, Massachusetts General Hospital, Boston, MA, United States, 5Laboratory for Vascular Translational Science (LVTS), Institut National de la Santé et de la Recherche Médicale (INSERM), Paris, France, 6Department of Radiology, Brigham and Women’s Hospital, Boston, MA, United States

Breast cancers are complex, evolving systems characterized by profound spatial and temporal heterogeneity in their biological nature. A multimodal multiparametric approach is needed to synergistically use imaging methods with different biophysical basis to simultaneously quantify multiple aspects of tumor physiology. We built a custom breast coil to allow multimodal near-infrared diffuse optical tomography and MR elastography imaging of human breast. Results of a three-inclusion dual-contrast phantom showed clear contrasts in reconstructed mechanical and optical properties as expected. Data on a breast cancer patient showed collocated hemoglobin and stiffness contrast at the tumor location.

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