Abstract #0092

R2* mapping of the whole brain with 0.8 mm isotropic resolution at 7T in less than 7 minutes

Arun Joseph^1,2,3, Tobias Kober^4,5,6, and Tom Hilbert^4,5,6

¹Advanced Clinical Imaging Technology, Siemens Healthcare AG, Bern, Switzerland, ²Translational Imaging Center, Sitem-Insel, Bern, Switzerland, ³Departments of Radiology and Biomedical Research, University of Bern, Bern, Switzerland, ⁴Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland, ⁵Department of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland, ⁶LTS5, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland

T2*-weighted imaging is an important diagnostic tool to evaluate normal and pathological tissues due to its sensitivity to iron deposition. This comes with high sensitivity to magnetic field inhomogeneities within a voxel, resulting in susceptibility artifacts. These artefacts are largely reduced at higher resolutions; high-resolution protocols however lead to clinically unfeasible scan times with multi-echo gradient echo sequences. Here, we propose a compressed sensing multi-echo GRE acquisition for 7T to obtain 0.8 mm isotropic R2* maps of the whole brain in <7 minutes and with substantially reduced artefacts. Preliminary qualitative and quantitative validations are performed on healthy subjects.

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