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Abstract #0092

R2* mapping of the whole brain with 0.8 mm isotropic resolution at 7T in less than 7 minutes

Arun Joseph1,2,3, Tobias Kober4,5,6, and Tom Hilbert4,5,6
1Advanced Clinical Imaging Technology, Siemens Healthcare AG, Bern, Switzerland, 2Translational Imaging Center, Sitem-Insel, Bern, Switzerland, 3Departments of Radiology and Biomedical Research, University of Bern, Bern, Switzerland, 4Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland, 5Department of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland, 6LTS5, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland

T2*-weighted imaging is an important diagnostic tool to evaluate normal and pathological tissues due to its sensitivity to iron deposition. This comes with high sensitivity to magnetic field inhomogeneities within a voxel, resulting in susceptibility artifacts. These artefacts are largely reduced at higher resolutions; high-resolution protocols however lead to clinically unfeasible scan times with multi-echo gradient echo sequences. Here, we propose a compressed sensing multi-echo GRE acquisition for 7T to obtain 0.8 mm isotropic R2* maps of the whole brain in <7 minutes and with substantially reduced artefacts. Preliminary qualitative and quantitative validations are performed on healthy subjects.

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