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Abstract #0133

Inductively coupled detectors for optogenetic-driven focal and multiregional fMRI signal enhancement

Yi Chen1, Qi Wang1,2, Hang Zeng1,2, Kengo Takahashi1,2, Sangcheon Choi1,2, Chunqi Qian3, and Xin Yu1,4
1Max Planck Institute for Biological Cybernetics, Tuebingen, Germany, 2Graduate Training Centre of Neuroscience, University of Tuebingen, Tuebingen, Germany, 3Department of Radiology, Michigan State University, East Lansing, MI, United States, 4Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States

To improve MR detection sensitivity of multi-modal fMRI platform, we present inductive coil which could relay locally detected MR signals to the external surface coil. Under sensory stimulation, evoked whole brain EPI-based fMRI and enhanced focal laminar-specific fMRI signals were acquired with high spatiotemporal resolution (100 μm and 100 ms) using a single experimental setup. Moreover, embedding inductive coil beneath the glue-secured optical fiber and the projection-mirrored cortex on the other hemisphere boosted multiregional fMRI sensitivity to investigate the interhemispheric connectivity with laminar-specificity. This is particularly helpful to study the optogenetic-driven brain connectivity with circuit specificity at multi-modal fMRI platform.

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