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Abstract #0140

Quantitative DCE and DW-MRI to Evaluate Suspicious Mammographic Calcifications: Results from a Single Institution Prospective Clinical Trial

Janis M. Yee1, Daniel S. Hippe1, Michael Hirano1, Bonny Chau1, Debosmita Biswas1, Anum S. Kazerouni1, Mary Lynn Bryant1, Isabella Li1, Jennifer Xiao1, Wei Huang2, Savannah C. Partridge1, and Habib Rahbar1
1Radiology, University of Washington, Seattle, WA, United States, 2Oregon Health & Science University, Portland, OR, United States

Mammographic calcifications remain a diagnostic dilemma with low positive predictive value for malignancy. Our study investigated the use of quantitative DCE and DW-MRI metrics to problem solve suspicious calcifications prior to biopsy. In patients with a suspicious enhancing MRI correlate, malignant lesions exhibited higher peak PE, peak SER, functional tumor volume, and Ktrans. Basic and advanced 3D DW-MRI parameters did not yield statistically significant discriminatory values in this small pilot study. Use of quantitative MRI features shows potential to reduce the number of unnecessary biopsies for suspicious mammographic calcifications among the subset that demonstrate suspicious enhancement.

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