Mammographic calcifications remain a diagnostic dilemma with low positive predictive value for malignancy. Our study investigated the use of quantitative DCE and DW-MRI metrics to problem solve suspicious calcifications prior to biopsy. In patients with a suspicious enhancing MRI correlate, malignant lesions exhibited higher peak PE, peak SER, functional tumor volume, and Ktrans. Basic and advanced 3D DW-MRI parameters did not yield statistically significant discriminatory values in this small pilot study. Use of quantitative MRI features shows potential to reduce the number of unnecessary biopsies for suspicious mammographic calcifications among the subset that demonstrate suspicious enhancement.
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