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Abstract #0150

Non-invasive mapping of cerebral glucose transport and metabolism using glucoCESL MRI

Ben R Dickie1,2, Tao Jin3, Rainer Hinz4, Geoff JM Parker5,6, Laura M Parkes1,2, and Julian Matthews1,2
1Division of Neuroscience and Experimental Psychology, Faculty of Biology Medicine and Health, The University of Manchester, Manchester, United Kingdom, 2Geoffrey Jefferson Brain Research Centre, Manchester Academic Health Science Centre, Manchester, United Kingdom, 3Department of Radiology, University of Pittsburgh, Pittsburgh, PA, United States, 4Division of Informatics, Imaging, and Data Sciences, Faculty of Biology, Medicine, and Health, The University of Manchester, Manchester, United Kingdom, 5Centre for Medical Image Computing, Department of Computer Science and Department of Neuroinflammation, University College London, London, United Kingdom, 6Bioxydyn Ltd, Manchester, United Kingdom

Chemical-exchange spin-lock (CESL) MRI can detect uptake and clearance of intravenously administered glucose into the brain at high spatial resolution. We apply quantitative modelling to describe glucoCESL kinetics in tumour-bearing and healthy rats. Parameters relating to glucose transport (Tmax, Kt, kd), metabolism (MRglu) and blood volume (vb) were estimated and compared between tumour and cortical tissue. Kinetic modelling of glucoCESL MRI data yields meaningful estimates of glucose transport and metabolism, and our modelling approach holds great promise to probe glucose transport and metabolism at high spatial resolution.

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