We applied a three compartment intravoxel incoherent motion (IVIM) technique that estimated the perfusion fraction (PF), free water (FW), and anisotropic diffusion of tissue (FAt) to detect microvascular and microstructural changes in a cohort of 54 psychotic spectrum disorder (PSD) patients compared to 35 healthy controls (HC). We found significantly increased PF, FW and FAt in PSD and PSD subtypes compared to HC, primarily in the frontal and temporal lobes and cingulate and insular cortices at multiple comparisons correction level. In patients, IVIM metrics were found to be associated with the duration of psychosis and performance on several cognitive tests.
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