Abstract #0259

Evaluation of muscle oxygen extraction fraction in response to 15 weeks of exercise training: Comparison of people with and without type 2 diabetes

Erin K Englund¹, Deirdre Rafferty², Jie Zheng³, Hongyu An³, Judith G Regensteiner^2,4, Alex J Barker^1,5, and Jane EB Reusch^2,4

¹Department of Radiology, University of Colorado Anschutz Medical Campus, Aurora, CO, United States, ²Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, United States, ³Department of Radiology, Washington University in St. Louis, St. Louis, MO, United States, ⁴Center for Women’s Health Research, University of Colorado Anschutz Medical Campus, Aurora, CO, United States, ⁵Department of Bioengineering, University of Colorado Anschutz Medical Campus, Aurora, CO, United States

Oxygen extraction fraction (OEF) provides insight into muscle oxygen consumption. As part of a larger exercise training study, 16 sedentary participants (12 controls, 4 with diabetes) underwent an MRI scan to determine OEF before and after 15 weeks of supervised exercise training. Pilot MRI data were acquired at rest with an asymmetric spin echo sequence and used to calculate OEF in the medial gastrocnemius muscle. Cardiovascular exercise capacity, measured as VO₂Peak, was reduced in people with diabetes. MRI-measured OEF did not differ between groups, however a decrease in OEF was observed in all participants in response to exercise training.

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