Limbic-predominant age-related TDP-43 encephalopathy neuropathological change (LATE-NC) is now recognized as a common age-related neuropathology that has been linked to cognitive decline and dementia. In this work, the spatial pattern of R2 alterations associated with LATE-NC was investigated in a large (N=797) community cohort of older adults. Voxel-wise analysis revealed a pattern of lower R2 for greater LATE-NC burden, controlling for all other neuropathologies and demographics. This pattern involved mainly the temporal, frontal, occipital lobes and basal ganglia. To our knowledge this is the first R2 investigation in LATE-NC.