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Abstract #0283

Diffusion-weighted Echo Planar Spectroscopic Imaging Using semi‐LASER Localization at 3T: A Pilot Study

Manoj Kumar Sarma1,2, Andres Saucedo3, and M. Albert Albert Thomas3
1Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States, 2Radiology, UT Southwestern Medical Center, Dallas, TX, United States, 3Radiology, UCLA School of Medicine, Los Angeles, CA, United States

Diffusion-weighted spectroscopy (DW-MRS) is an excellent tool to explore the compartment specific assessment of tissue microstructure. Although there has been growing interest in DW-MRS for clinical applications, most of the studies involving human brain metabolites so far have used single-voxel methods, which limit its application to specific white matter tracts or arbitrarily selected regions of interest. There has been only a few attempts to evaluate the diffusion properties of brain metabolites with DW-MRSI. Here, we propose an echo planar-based diffusion-weighted spectroscopic imaging using semi-LASER localization and bipolar diffusion gradients. Initial results show good spectral quality and spatial localization.

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