Abstract #0302

Phase-contrast MR angiography at 7 Tesla revealed reduced lenticulostriate artery blood flow velocity in patients with small vessel disease

Yue Wu^1,2,3, Chengyue Sun⁴, Qingle Kong⁵, Zhixin Li^1,2,3, Dongbiao Sun^1,2,3, Chen Ling⁴, Jing An⁶, Rong Xue^1,2,3, Yan Zhuo^1,2,3, Yun Yuan⁴, and Zihao Zhang^1,2,3

¹State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China, ²The Innovation Center of Excellence on Brain Science, Chinese Academy of Sciences, Beijing, China, ³University of Chinese Academy of Sciences, Beijing, China, ⁴Department of Neurology, Peking University First Hospital, Beijing, China, ⁵MR Collaboration, Siemens Healthcare Ltd, Beijing, China, ⁶Siemens Shenzhen Magnetic Resonance Ltd, Shenzhen, China

In this study, we demonstrated a technique that could non-invasively quantify lenticulostriate artery (LSA) flow velocities in cerebral small vessel disease (CSVD). With phase-contrast magnetic resonance angiography (PC-MRA) at 7T, LSA blood flow velocities were detected in patients with CADASIL (a hereditary CSVD). LSA flow velocities decreased in patients compared with healthy individuals. We also found good associations between velocities and clinical characteristics among patients with CADASIL. These results suggest that PC-MRA at 7T is a valuable technique to assess small arterial dysfunction in patients with CSVD.

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