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Abstract #0302

Phase-contrast MR angiography at 7 Tesla revealed reduced lenticulostriate artery blood flow velocity in patients with small vessel disease

Yue Wu1,2,3, Chengyue Sun4, Qingle Kong5, Zhixin Li1,2,3, Dongbiao Sun1,2,3, Chen Ling4, Jing An6, Rong Xue1,2,3, Yan Zhuo1,2,3, Yun Yuan4, and Zihao Zhang1,2,3
1State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China, 2The Innovation Center of Excellence on Brain Science, Chinese Academy of Sciences, Beijing, China, 3University of Chinese Academy of Sciences, Beijing, China, 4Department of Neurology, Peking University First Hospital, Beijing, China, 5MR Collaboration, Siemens Healthcare Ltd, Beijing, China, 6Siemens Shenzhen Magnetic Resonance Ltd, Shenzhen, China

In this study, we demonstrated a technique that could non-invasively quantify lenticulostriate artery (LSA) flow velocities in cerebral small vessel disease (CSVD). With phase-contrast magnetic resonance angiography (PC-MRA) at 7T, LSA blood flow velocities were detected in patients with CADASIL (a hereditary CSVD). LSA flow velocities decreased in patients compared with healthy individuals. We also found good associations between velocities and clinical characteristics among patients with CADASIL. These results suggest that PC-MRA at 7T is a valuable technique to assess small arterial dysfunction in patients with CSVD.

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