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Abstract #0310

Abnormal aortic hemodynamics at predilection sites for dissection in Marfan patients: a 4D flow study

Pim van Ooij1, Mitzi van Andel2, Lukas M. Gottwald1, Aart J Nederveen1, and Maarten Groenink1
1Radiology & Nuclear Medicine, Amsterdam University Medical Centers, location AMC, Amsterdam, Netherlands, 2Cardiology, Amsterdam University Medical Centers, location AMC, Amsterdam, Netherlands

In this study we use 4D flow MRI techniques to investigate abnormal magnitude and direction of blood flow velocity and wall shear stress in patients with Marfan syndrome, a congenital disease that may cause aortic dissection. We found that patients that underwent aortic root repair have significantly more abnormal hemodynamics and that abnormally elevated hemodynamics were associated with blood pressure chracteristics. Abnormally directed hemodynamics were not associated with any patient characteristics, but showed a distinct regional increase at the inner proximal descending aorta, awell-know predilection site for aortic dissection in Marfan patients.

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